Title : Replacement of Phe274 with conserved residue Tyr274 for reactive center loop expulsion in antithrombin.

Pub. Date : 2011 Jun

PMID : 20211924






1 Functional Relationships(s)
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1 Antithrombin"s ability to form sodium dodecyl sulfate (SDS)-stable complex with thrombin, stoichiometry of thrombin inhibition, second-order rate constant for thrombin and factor Xa (fXa) inhibition (M(-1) s(-1)), and heparin dissociation constant (K(D); tryptophan fluorescence emission spectra) were determined. Tryptophan coagulation factor II, thrombin Homo sapiens