Title : [Expression of Gemcitabine-resistance-related gene and polymorphism of ribonucleotide reductase M1 gene promoter in Gemcitabine-resistant A549/Gem and NCI-H460/Gem cell lines].

Pub. Date : 2010 Jan

PMID : 20211060






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The expression of CDA, RRM1, PTEN and ERCC1 varied along with the changing gemcitabine resistance indexes, but expression of dCK did not change apparently. gemcitabine ribonucleotide reductase catalytic subunit M1 Homo sapiens
2 CONCLUSION: Compared with their parental cells, the expressions of CDA, RRM1, PTEN and ERCC1 in human gemcitabine-resistant non-small cell lung cancer cell lines A549/Gem and NCI-H460/Gem rise, the expression of dCK changes inapparently, therefore, their gene type are remaining wild type. gemcitabine ribonucleotide reductase catalytic subunit M1 Homo sapiens