Pub. Date : 2010 Apr 27
PMID : 20210363
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bile acids stimulate ATP hydrolysis in the purified cholesterol transporter ABCG5/G8. | Bile Acids and Salts | ATP binding cassette subfamily G member 5 | Homo sapiens |
| 2 | Previous studies demonstrated that bile acids increased ABCG5/G8 specific cholesterol efflux in cell models. | Bile Acids and Salts | ATP binding cassette subfamily G member 5 | Homo sapiens |
| 3 | In this study we tested the effects of bile acids on ATP hydrolysis in Pichia pastoris purified ABCG5/G8 and found that they stimulated hydrolysis approximately 20-fold in wild-type ABCG5/G8 but not in a hydrolysis-deficient mutant. | Bile Acids and Salts | ATP binding cassette subfamily G member 5 | Homo sapiens |
| 4 | In this study we tested the effects of bile acids on ATP hydrolysis in Pichia pastoris purified ABCG5/G8 and found that they stimulated hydrolysis approximately 20-fold in wild-type ABCG5/G8 but not in a hydrolysis-deficient mutant. | Bile Acids and Salts | ATP binding cassette subfamily G member 5 | Homo sapiens |
| 5 | The data demonstrate that bile acids together with lipids and cholesterol increase ATP hydrolysis in purified ABCG5/G8. | Bile Acids and Salts | ATP binding cassette subfamily G member 5 | Homo sapiens |
| 6 | Bile acids may promote an active conformation of purified ABCG5/G8 either by global stabilization of the transporter or by binding to a specific site on ABCG5/G8. | Bile Acids and Salts | ATP binding cassette subfamily G member 5 | Homo sapiens |
| 7 | Bile acids may promote an active conformation of purified ABCG5/G8 either by global stabilization of the transporter or by binding to a specific site on ABCG5/G8. | Bile Acids and Salts | ATP binding cassette subfamily G member 5 | Homo sapiens |