Title : Radiation-induced bystander signaling pathways in human fibroblasts: a role for interleukin-33 in the signal transmission.

Pub. Date : 2010 Jul

PMID : 20206688






1 Functional Relationships(s)
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1 The NF-kappaB-dependent gene expression of IL8, IL6, PTGS2/COX2, TNF and IL33 in directly irradiated human skin fibroblasts produced the cytokines and prostaglandin E2 (PGE2) with autocrine/paracrine functions, which further activated signaling pathways and induced NF-kappaB-dependent gene expression in bystander cells. Dinoprostone tumor necrosis factor Homo sapiens