Title : Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways.

Pub. Date : 2010 Aug 28

PMID : 20202741






1 Functional Relationships(s)
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1 In this work, we show that inhibition of EGFR with tyrphostin AG1478 enhances oridonin-induced cell death in human laryngeal cancer cells HEp-2, a cell line characterized by EGFR gene amplification. Tyrphostins epidermal growth factor receptor Homo sapiens