Title : Hyperglycemia impairs acetylcholine-induced vasodilation of retinal arterioles through polyol pathway-independent mechanisms in rats.

Pub. Date : 2010

PMID : 20197634






1 Functional Relationships(s)
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1 The attenuation of retinal vascular responses to ACh were not modified by treatment with GP-1447, whereas the aldose reductase inhibitor completely prevented diabetes-induced thinning of the retina and sorbitol accumulation in the retina and the lens. Sorbitol aldo-keto reductase family 1 member B1 Rattus norvegicus