Pub. Date : 2010 Mar
PMID : 20197013
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of saquinavir/ritonavir on P-glycoprotein activity in healthy volunteers using digoxin as a probe. | Saquinavir | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | BACKGROUND: Saquinavir and ritonavir, both human immunodeficiency virus-1 protease inhibitors, also inhibit the adenosine triphosphate-dependent efflux pump P-glycoprotein (P-gp), which is located at a variety of anatomic sites, including the human intestine. | Saquinavir | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | BACKGROUND: Saquinavir and ritonavir, both human immunodeficiency virus-1 protease inhibitors, also inhibit the adenosine triphosphate-dependent efflux pump P-glycoprotein (P-gp), which is located at a variety of anatomic sites, including the human intestine. | Saquinavir | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | CONCLUSIONS: Pretreatment with saquinavir/ritonavir 1,000/100 mg twice daily increased digoxin exposure most likely via P-gp-inhibition. | Saquinavir | ATP binding cassette subfamily B member 1 | Homo sapiens |