Title : Thioredoxin reductase inhibitor ethaselen increases the drug sensitivity of the colon cancer cell line LoVo towards cisplatin via regulation of G1 phase and reversal of G2/M phase arrest.

Pub. Date : 2011 Aug

PMID : 20195699






1 Functional Relationships(s)
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1 In appropriate conditions, CDDP induced arrest at the G2/M phase accompanied by the enhanced inhibitory phosphorylation of Cdk1 and the elevated protein expression of cyclin B1. Cisplatin cyclin dependent kinase 1 Homo sapiens