Title : Restoration of mutant cytochrome P450 reductase activity by external flavin.

Pub. Date : 2010 Jun 10

PMID : 20188793






1 Functional Relationships(s)
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1 Here we are reporting that mutations in the FMN binding domain of POR may reduce CYP3A4 activity, potentially influencing drug and steroid metabolism; and the loss of CYP3A4 activity may be correlated to the reduction of cytochrome b(5) by POR. Steroids cytochrome P450 family 3 subfamily A member 4 Homo sapiens