Pub. Date : 2010 Apr 15
PMID : 20186883
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | GADD45alpha mediates arsenite-induced cell apoptotic effect in human hepatoma cells via JNKs/AP-1-dependent pathway. | arsenite | growth arrest and DNA damage inducible alpha | Homo sapiens |
| 2 | In this study, we have disclosed that arsenite effectively induces the apoptotic response in the HepG2 human hepatoma cells by triggering GADD45alpha induction and the subsequent activation of JNKs/AP-1 cell death pathway. | arsenite | growth arrest and DNA damage inducible alpha | Homo sapiens |
| 3 | However, signaling events relating to GADD45alpha/JNKs/AP-1 pathway activation have not been observed in HL7702 human diploid hepatic cells under the same arsenite exposure condition. | arsenite | growth arrest and DNA damage inducible alpha | Homo sapiens |
| 4 | Our results thus have illustrated the selective pro-apoptotic role of arsenite in the hepatoma cells by activating GADD45alpha-dependent cell death pathway whereas with little effect on the normal hepatic cells. | arsenite | growth arrest and DNA damage inducible alpha | Homo sapiens |
| 5 | The approaches to up-regulate GADD45alpha levels might be helpful in improving the chemotherapeutic action of arsenite on certain solid tumors including hepatoma. | arsenite | growth arrest and DNA damage inducible alpha | Homo sapiens |