Title : Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway.

Pub. Date : 2010 May

PMID : 20185792






3 Functional Relationships(s)
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1 Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway. acadesine AKT serine/threonine kinase 1 Homo sapiens
2 In endothelial cells and macrophages, acadesine activated the phosphoinositide 3-kinase/Akt signaling pathway, reduced the activity of mitogen-activated protein kinases, and consequently suppressed TF expression by inhibiting the activator protein-1 and NF-kappaB pathways. acadesine AKT serine/threonine kinase 1 Homo sapiens
3 CONCLUSION: Acadesine inhibits TF expression and thrombus formation by activating the phosphoinositide 3-kinase/Akt pathway. acadesine AKT serine/threonine kinase 1 Homo sapiens