Pub. Date : 2010 May
PMID : 20185792
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway. | acadesine | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | In endothelial cells and macrophages, acadesine activated the phosphoinositide 3-kinase/Akt signaling pathway, reduced the activity of mitogen-activated protein kinases, and consequently suppressed TF expression by inhibiting the activator protein-1 and NF-kappaB pathways. | acadesine | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | CONCLUSION: Acadesine inhibits TF expression and thrombus formation by activating the phosphoinositide 3-kinase/Akt pathway. | acadesine | AKT serine/threonine kinase 1 | Homo sapiens |