Title : Dextran sulfate sodium and 2,4,6-trinitrobenzene sulfonic acid induce lipid peroxidation by the proliferation of intestinal gram-negative bacteria in mice.

Pub. Date : 2010 Feb 1

PMID : 20181058






2 Functional Relationships(s)
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1 RESULTS: DSS and TNBS induced the protein expression of TLR-4 and activated transcription factor NF-kappaB. Trinitrobenzenesulfonic Acid nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
2 DISCUSSION: These findings suggest that DSS and TNBS may cause colitis by inducing lipid peroxidation and enterobacterial proliferation, which may deteriorate the colitis by regulating proinflammatory cytokines via TLR-4-linked NF-kappaB activation pathway. Trinitrobenzenesulfonic Acid nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus