Title : Pyk2 uncouples metabotropic glutamate receptor G protein signaling but facilitates ERK1/2 activation.

Pub. Date : 2010 Jan 21

PMID : 20180987






1 Functional Relationships(s)
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1 Pyk2 overexpression in HEK293 results in attenuated basal and agonist-stimulated inositol phosphate formation in mGluR1 expressing cells and involves a mechanism whereby Pyk2 displaces Galphaq/11 from the receptor. Inositol Phosphates glutamate metabotropic receptor 1 Homo sapiens