Title : RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.

Pub. Date : 2010 Mar 18

PMID : 20179705






2 Functional Relationships(s)
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1 We found that ATP-competitive RAF inhibitors inhibit ERK signalling in cells with mutant BRAF, but unexpectedly enhance signalling in cells with wild-type BRAF. Adenosine Triphosphate mitogen-activated protein kinase 1 Homo sapiens
2 Induction of ERK signalling requires direct binding of the drug to the ATP-binding site of one kinase of the dimer and is dependent on RAS activity. Adenosine Triphosphate mitogen-activated protein kinase 1 Homo sapiens