Pub. Date : 2010 Mar 1
PMID : 20179211
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DATS also diminished TPA-induced expression of c-Jun and c-Fos, the principal components of AP-1, and blunted the activation of c-Jun NH(2)-terminal kinase (JNK) and Akt. | Tetradecanoylphorbol Acetate | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | Pharmacologic inhibition of JNK or Akt by SP600125 or LY294002, respectively, resulted in diminished AP-1 DNA binding, reduced levels of c-Jun and c-Fos, and inhibition of COX-2 expression in TPA-treated mouse skin. | Tetradecanoylphorbol Acetate | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | The JNK or Akt kinase assay, taking c-Jun fusion protein as a substrate, revealed that TPA induced JNK- or Akt-mediated c-Jun phosphorylation in mouse skin, which was significantly attenuated by DATS or respective pharmacologic inhibitors. | Tetradecanoylphorbol Acetate | thymoma viral proto-oncogene 1 | Mus musculus |
| 4 | The JNK or Akt kinase assay, taking c-Jun fusion protein as a substrate, revealed that TPA induced JNK- or Akt-mediated c-Jun phosphorylation in mouse skin, which was significantly attenuated by DATS or respective pharmacologic inhibitors. | Tetradecanoylphorbol Acetate | thymoma viral proto-oncogene 1 | Mus musculus |
| 5 | Taken together, the inhibitory effects of DATS on TPA-induced AP-1 activation and COX-2 expression through modulation of JNK or Akt signaling may partly account for its antitumor-promoting effect on mouse skin carcinogenesis. | Tetradecanoylphorbol Acetate | thymoma viral proto-oncogene 1 | Mus musculus |