Title : The prolyl isomerase Pin1 enhances HER-2 expression and cellular transformation via its interaction with mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1.

Pub. Date : 2010 Mar

PMID : 20179161






1 Functional Relationships(s)
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1 The phosphorylation of proteins on the serine or threonine residues that immediately precede proline (pSer/Thr-Pro) is specifically catalyzed by the prolyl isomerase Pin1 and is a key signaling mechanism in cell proliferation and transformation. Proline peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Homo sapiens