Title : Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration.

Pub. Date : 2010 Mar 15

PMID : 20179103






2 Functional Relationships(s)
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1 However, only active Mek2 could bind Pin1, acting as a scaffold to bridge Pin1 and BPGAP1 in a manner that involves the release of an autoinhibited proline-rich motif, 186-PPLP-189, proximal to the RhoGAP domain. Proline peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Homo sapiens
2 This allows the non-canonical 186-PPLP-189 and 256-DDYGD-260 motifs of the proline-rich region and RhoGAP domain of BPGAP1 to become accessible to concerted binding by the WW and PPI domains of Pin1, respectively. Proline peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Homo sapiens