Title : Cbl-b promotes chemotherapy-induced apoptosis in rat basophilic leukemia cells by suppressing PI3K/Akt activation and enhancing MEK/ERK activation.

Pub. Date : 2010 Jul

PMID : 20177738






2 Functional Relationships(s)
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1 In this study, VP-16-induced RBL-2H3 cells apoptosis was accompanied by the activation of Akt and ERK. Etoposide AKT serine/threonine kinase 1 Rattus norvegicus
2 Over expression of Cbl-b significantly enhanced VP-16-induced cell apoptosis with inhibition of Akt activity, while a dominant negative (DN) RING Finger domain mutation completely abolished this enhancement. Etoposide AKT serine/threonine kinase 1 Rattus norvegicus