Title : Ovarian cancer-derived lysophosphatidic acid stimulates secretion of VEGF and stromal cell-derived factor-1 alpha from human mesenchymal stem cells.

Pub. Date : 2010 Apr 30

PMID : 20177148






2 Functional Relationships(s)
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1 Moreover, LPA-induced alpha-SMA expression was abrogated by treatment with the ERK inhibitor U0126 or the phosphoinositide-3-kinase inhibitor LY294002, but not the PLC inhibitor U73122. lysophosphatidic acid mitogen-activated protein kinase 1 Homo sapiens
2 These results suggest that cancer-secreted LPA induces differentiation of hASCs to cancer-associated fibroblasts through multiple signaling pathways involving Rho kinase, ERK, PLC, and phosphoinositide-3-kinase. lysophosphatidic acid mitogen-activated protein kinase 1 Homo sapiens