Title : Ovarian cancer-derived lysophosphatidic acid stimulates secretion of VEGF and stromal cell-derived factor-1 alpha from human mesenchymal stem cells.

Pub. Date : 2010 Apr 30

PMID : 20177148






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Ovarian cancer-derived lysophosphatidic acid stimulates secretion of VEGF and stromal cell-derived factor-1 alpha from human mesenchymal stem cells. lysophosphatidic acid vascular endothelial growth factor A Homo sapiens
2 LPA activated RhoA in hASCs and pretreatment with the Rho kinase inhibitor Y27632 completely abrogated the LPA-induced expression of alpha-SMA, SDF-1, and VEGF in hASCs. lysophosphatidic acid vascular endothelial growth factor A Homo sapiens
3 LPA-induced VEGF secretion was inhibited by LY294002, whereas LPA-induced SDF-1 secretion was markedly attenuated by U0126, U73122, and LY294002. lysophosphatidic acid vascular endothelial growth factor A Homo sapiens