Title : Substitution of the Bordetella pertussis lipid A phosphate groups with glucosamine is required for robust NF-kappaB activation and release of proinflammatory cytokines in cells expressing human but not murine Toll-like receptor 4-MD-2-CD14.

Pub. Date : 2010 May

PMID : 20176798






1 Functional Relationships(s)
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1 We found inactivated B. pertussis cells to be stronger inducers of proinflammatory cytokines in THP-1-derived macrophages when lipid A was modified. Lipid A GLI family zinc finger 2 Homo sapiens