Title : Effect of fluconazole on the pharmacokinetics of halofantrine in healthy volunteers.

Pub. Date : 2009 Dec

PMID : 20175801






2 Functional Relationships(s)
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1 Fluconazole, an antifungal agent and an inhibitor of CYP3A4 is an established part of the therapy in HIV patients, who in turn are prone to malaria in the tropics. Fluconazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 CONCLUSION: The decreased plasma concentrations of the metabolite are presumably caused by metabolic inhibition of CYP3A4 by fluconazole. Fluconazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens