Title : Effect of fluconazole on the pharmacokinetics of halofantrine in healthy volunteers.

Pub. Date : 2009 Dec

PMID : 20175801






1 Functional Relationships(s)
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1 BACKGROUND: Halofantrine, an antimalarial drug used in endemic areas such as the tropics is mainly metabolized by CYP3A4 to the active metabolite N-desbutylhalofantrine. 1,3-dichloro-6-trifluoromethyl-9-phenanthryl-3-(n-butyl)aminopropanol cytochrome P450 family 3 subfamily A member 4 Homo sapiens