Title : In vitro metabolism and identification of human enzymes involved in the metabolism of methylnaltrexone.

Pub. Date : 2010 May

PMID : 20173089






1 Functional Relationships(s)
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1 Formation of M4 and M5 was catalyzed by NADPH-dependent hepatic cytosolic enzymes, which were identified using selective chemical inhibitors (10 and 100 microM) for aldo-keto reductase (AKR) isoforms, short-chain dehydrogenase/reductase including carbonyl reductase, alcohol dehydrogenase, and quinone oxidoreductase. NADP aldo-keto reductase family 1 member A1 Homo sapiens