Title : TSU-16, (Z)-3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-2-indolinone, is a potent activator of aryl hydrocarbon receptor and increases CYP1A1 and CYP1A2 expression in human hepatocytes.

Pub. Date : 2010 Apr 15

PMID : 20171196






1 Functional Relationships(s)
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1 The extent of increase and profiles of the time-dependent changes in CYP1A1 and CYP1A2 mRNA levels after TSU-16 treatment were similar to those after treatment with 3-methylcholanthrene (3MC), a well-known activator of the aryl hydrocarbon receptor (AhR). 3-((2,4-dimethylpyrrol-5-yl)methylidenyl)-2-indolinone cytochrome P450 family 1 subfamily A member 1 Homo sapiens