Pub. Date : 2009
PMID : 20168983
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rottlerin inhibits ROS formation and prevents NFkappaB activation in MCF-7 and HT-29 cells. | rottlerin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Among them, we recently found that Rottlerin inhibits the Nuclear Factor kappaB (NFkappaB), activated by either phorbol esters or H(2)O(2). | rottlerin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Among them, we recently found that Rottlerin inhibits the Nuclear Factor kappaB (NFkappaB), activated by either phorbol esters or H(2)O(2). | rottlerin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | Because of the redox sensitivity of NFkappaB and on the basis of Rottlerin antioxidant property, we hypothesized that Rottlerin could prevent NFkappaB activation acting as a free radicals scavenger, as other natural polyphenols. | rottlerin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | Because of the redox sensitivity of NFkappaB and on the basis of Rottlerin antioxidant property, we hypothesized that Rottlerin could prevent NFkappaB activation acting as a free radicals scavenger, as other natural polyphenols. | rottlerin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 6 | We also demonstrate that Rottlerin prevents TNFalpha-dependent NFkappaB activation in MCF-7 cells and in HT-29 cells transfected with the NFkappaB-driven plasmid pBIIX-LUC, suggesting that Rottlerin can inhibit NFkappaB via several pathways and in several cell types. | rottlerin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 7 | We also demonstrate that Rottlerin prevents TNFalpha-dependent NFkappaB activation in MCF-7 cells and in HT-29 cells transfected with the NFkappaB-driven plasmid pBIIX-LUC, suggesting that Rottlerin can inhibit NFkappaB via several pathways and in several cell types. | rottlerin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 8 | We also demonstrate that Rottlerin prevents TNFalpha-dependent NFkappaB activation in MCF-7 cells and in HT-29 cells transfected with the NFkappaB-driven plasmid pBIIX-LUC, suggesting that Rottlerin can inhibit NFkappaB via several pathways and in several cell types. | rottlerin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 9 | We also demonstrate that Rottlerin prevents TNFalpha-dependent NFkappaB activation in MCF-7 cells and in HT-29 cells transfected with the NFkappaB-driven plasmid pBIIX-LUC, suggesting that Rottlerin can inhibit NFkappaB via several pathways and in several cell types. | rottlerin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 10 | We also demonstrate that Rottlerin prevents TNFalpha-dependent NFkappaB activation in MCF-7 cells and in HT-29 cells transfected with the NFkappaB-driven plasmid pBIIX-LUC, suggesting that Rottlerin can inhibit NFkappaB via several pathways and in several cell types. | rottlerin | nuclear factor kappa B subunit 1 | Homo sapiens |