Title : Progress in COX-2 inhibitors: a journey so far.

Pub. Date : 2010

PMID : 20166930






1 Functional Relationships(s)
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1 Observation of increased cardiovascular risks in APPROVe (Adenomatous Polyp Prevention on Vioxx) study sent tremors and led to voluntary withdrawn of Vioxx (rofecoxib) by Merck from the market in September 2004 followed by Bextra (valdecoxib) in 2005 raising a question on the safety of selective COX-2 inhibitors. rofecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens