Title : Effects of simvastatin on the pharmacokinetics of verapamil and its main metabolite, norverapamil, in rats.

Pub. Date : 2009 Jul-Sep

PMID : 20166433






2 Functional Relationships(s)
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1 These results implied that simvastatin significantly enhanced the oral bioavailability of verapamil by inhibiting the CYP3A-mediated metabolism in small intestine or in the liver and P-glycoprotein (P-gp) efflux pump in small intestine. Simvastatin ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus
2 These results implied that simvastatin significantly enhanced the oral bioavailability of verapamil by inhibiting the CYP3A-mediated metabolism in small intestine or in the liver and P-glycoprotein (P-gp) efflux pump in small intestine. Simvastatin ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus