Pub. Date : 2010 May
PMID : 20165829
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AIMS/HYPOTHESIS: Glucosamine, generated during hyperglycaemia, causes insulin resistance in different cells. | Glucosamine | insulin | Homo sapiens |
| 2 | Here we sought to evaluate the possible role of endoplasmic reticulum (ER) stress in the induction of insulin resistance by glucosamine in skeletal muscle cells. | Glucosamine | insulin | Homo sapiens |
| 3 | In addition, glucosamine impaired insulin-stimulated 2-DG uptake in both rat and human myotubes. | Glucosamine | insulin | Homo sapiens |
| 4 | Interestingly, pretreatment of both rat and human myotubes with the chemical chaperones 4-phenylbutyric acid (PBA) or tauroursodeoxycholic acid (TUDCA), completely prevented the effect of glucosamine on both ER stress induction and insulin-induced glucose uptake. | Glucosamine | insulin | Homo sapiens |
| 5 | CONCLUSIONS/INTERPRETATION: In this work we show that glucosamine-induced ER stress causes insulin resistance in both human and rat myotubes and impairs GLUT4 production and insulin-induced glucose uptake via an ATF6-dependent decrease of the GLUT4 regulators MEF2A and PGC1alpha. | Glucosamine | insulin | Homo sapiens |
| 6 | CONCLUSIONS/INTERPRETATION: In this work we show that glucosamine-induced ER stress causes insulin resistance in both human and rat myotubes and impairs GLUT4 production and insulin-induced glucose uptake via an ATF6-dependent decrease of the GLUT4 regulators MEF2A and PGC1alpha. | Glucosamine | insulin | Homo sapiens |