Title : Heme oxygenase-1/p21WAF1 mediates peroxisome proliferator-activated receptor-gamma signaling inhibition of proliferation of rat pulmonary artery smooth muscle cells.

Pub. Date : 2010 Mar

PMID : 20163460






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Like loss of HO-1, loss of p21(WAF1) through siRNA transfection also reversed the inhibitory effect of rosiglitazone on PASMC proliferation triggered by serotonin. pasmc KRAS proto-oncogene, GTPase Rattus norvegicus
2 Taken together, our findings suggest that activation of PPARgamma induces HO-1 expression, and that this in turn stimulates p21(WAF1) expression to suppress PASMC proliferation. pasmc KRAS proto-oncogene, GTPase Rattus norvegicus