Title : ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS.

Pub. Date : 2010 Mar 2

PMID : 20160076






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Reactive Oxygen Species TSC complex subunit 2 Mus musculus
2 Our results identify a cytoplasmic pathway for ROS-induced ATM activation of TSC2 to regulate mTORC1 signaling and autophagy, identifying an integration node for the cellular damage response with key pathways involved in metabolism, protein synthesis, and cell survival. Reactive Oxygen Species TSC complex subunit 2 Mus musculus