Title : Differential effects of prednisone and growth hormone on fuel metabolism and insulin antagonism in humans.

Pub. Date : 1991 Jan

PMID : 2015969






3 Functional Relationships(s)
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1 Human growth hormone (hGH) and prednisone cause insulin resistance and glucose intolerance. Prednisone insulin Homo sapiens
2 Plasma insulin concentrations were elevated during therapy with prednisone alone and rhGH alone (667 +/- 72 and 564 +/- 65 pmol/ml, respectively, P less than 0.001) compared with placebo (226 +/- 44 pmol/ml) but lower than with the combined rhGH and prednisone treatment (1249 +/- 54 pmol/ml, P less than 0.01). Prednisone insulin Homo sapiens
3 Plasma insulin concentrations were elevated during therapy with prednisone alone and rhGH alone (667 +/- 72 and 564 +/- 65 pmol/ml, respectively, P less than 0.001) compared with placebo (226 +/- 44 pmol/ml) but lower than with the combined rhGH and prednisone treatment (1249 +/- 54 pmol/ml, P less than 0.01). Prednisone insulin Homo sapiens