Title : Probiotic Pre-treatment Reduces Gliclazide Permeation (ex vivo) in Healthy Rats but Increases It in Diabetic Rats to the Level Seen in Untreated Healthy Rats.

Pub. Date : 2008 Jul

PMID : 20157366






1 Functional Relationships(s)
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1 DISCUSSION: In healthy rats, the reduction in Jss((MtoS)) after probiotics administration could be explained by the production of bacterial metabolites that upregulate the mucosal efflux drug transporters Mrp2 that control gliclazide transport. Gliclazide ATP binding cassette subfamily C member 2 Rattus norvegicus