Title : Investigations of low-frequency vibrational dynamics and ligand binding kinetics of cystathionine beta-synthase.

Pub. Date : 2010 Mar 11

PMID : 20155941






2 Functional Relationships(s)
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1 Normal coordinate structural decomposition (NSD) of the ferric CBS crystal structure predicts the enhancement of normal modes with significant heme "doming", "ruffling", and "saddling" content, and they are observed in the coherence spectra near approximately 40, approximately 60, and approximately 90 cm(-1). Ferric enterobactin ion cystathionine beta-synthase Homo sapiens
2 For ferric CBS, we observe a new mode near approximately 25 cm(-1), possibly involving the response of the protein, which exhibits a phase jump of approximately pi for excitation on the blue and red side of the Soret band maximum. Ferric enterobactin ion cystathionine beta-synthase Homo sapiens