Title : ERK-1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts.

Pub. Date : 2010 May

PMID : 20155832






1 Functional Relationships(s)
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1 The ERK-1/2 pathway inhibitor PD98059 significantly attenuated the hypertrophic changes induced by conditioned medium from OA SBOs, and the p38 inhibitor SB203580 resulted in the up-regulation of hypertrophic genes in ACCs. SB 203580 mitogen-activated protein kinase 1 Homo sapiens