Pub. Date : 2010 Apr
PMID : 20154146
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We identified the human OGFOD1 protein as a novel stress granule component that regulates the phosphorylation of eIF2alpha and the resumption of translation in cells recovering from arsenite-induced stress. | arsenite | eukaryotic translation initiation factor 2A | Homo sapiens |
| 2 | Overexpression of OGFOD1 led to increased abundance of phosphorylated eIF2alpha, both in unstressed cells and in cells exposed to arsenite-induced stress, and to accelerated apoptosis during stress. | arsenite | eukaryotic translation initiation factor 2A | Homo sapiens |
| 3 | These findings argue that OGFOD1 plays important proapoptotic roles in the regulation of translation and HRI-mediated phosphorylation of eIF2alpha in cells subjected to arsenite-induced stress. | arsenite | eukaryotic translation initiation factor 2A | Homo sapiens |