Title : Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism.

Pub. Date : 2010 Jun 1

PMID : 20153296






1 Functional Relationships(s)
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1 Interestingly, only a group of VEGF inhibitors, including apigenin, flavone and 4",7-dihydroxiflavone, reduced the expression of HIF-1alpha under these conditions, whereas others, such as fisetin, luteolin, galangin or quercetin, induced HIF-1alpha expression while reducing those of VEGF. Luteolin vascular endothelial growth factor A Homo sapiens