Title : Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism.

Pub. Date : 2010 Jun 1

PMID : 20153296






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We found that apigenin, luteolin, fisetin and quercetin inhibited hypoxia-induced VEGF expression in the low micromolar range. fisetin vascular endothelial growth factor A Homo sapiens
2 Interestingly, only a group of VEGF inhibitors, including apigenin, flavone and 4",7-dihydroxiflavone, reduced the expression of HIF-1alpha under these conditions, whereas others, such as fisetin, luteolin, galangin or quercetin, induced HIF-1alpha expression while reducing those of VEGF. fisetin vascular endothelial growth factor A Homo sapiens