Title : Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.

Pub. Date : 2010 Jan 14

PMID : 20152113






2 Functional Relationships(s)
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1 The density of GABA(A) receptors (GABA(A)Rs) at synapses regulates brain excitability, and altered inhibition may contribute to Huntington"s disease, which is caused by a polyglutamine repeat in the protein huntingtin. gamma-Aminobutyric Acid huntingtin Homo sapiens
2 When huntingtin is mutated, as in Huntington"s disease, GABA(A)R transport and inhibitory synaptic currents are reduced. gamma-Aminobutyric Acid huntingtin Homo sapiens