Pub. Date : 2010 May 14
PMID : 20150427
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. | Tolcapone | synuclein alpha | Homo sapiens |
2 | Here, we show that entacapone and tolcapone are potent inhibitors of alpha-syn and beta-amyloid (Abeta) oligomerization and fibrillogenesis, and they also protect against extracellular toxicity induced by the aggregation of both proteins. | Tolcapone | synuclein alpha | Homo sapiens |
3 | Our findings present the first characterization of the anti-amyloidogenic properties of tolcapone and entacapone against both alpha-synuclein and Abeta42 and highlight the potential of this class of nitro-catechol compounds as anti-amyloidogenic agents. | Tolcapone | synuclein alpha | Homo sapiens |