Title : Structural basis of human CYP51 inhibition by antifungal azoles.

Pub. Date : 2010 Apr 9

PMID : 20149798






1 Functional Relationships(s)
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1 Comparison of the azole-bound structures provides insight into the relative binding affinities of human and bacterial P450 enzymes to ketoconazole and fluconazole, which can be useful for the rational design of antifungal compounds and specific modulators of human CYP51. Azoles cytochrome P450 family 2 subfamily B member 6 Homo sapiens