Title : Hypocretins regulate the anxiogenic-like effects of nicotine and induce reinstatement of nicotine-seeking behavior.

Pub. Date : 2010 Feb 10

PMID : 20147556






2 Functional Relationships(s)
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1 Acute nicotine (0.8 mg/kg, s.c.) induced anxiogenic-like effects in the elevated plus-maze and activated the paraventricular nucleus of the hypothalamus (PVN) as revealed by c-Fos expression. Nicotine Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 In addition, an increase of the percentage of c-Fos-positive hypocretin cells in the perifornical and dorsomedial hypothalamic (PFA/DMH) areas was found after nicotine (0.8 mg/kg, s.c.) administration. Nicotine Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens