Title : Targeting acetylcholinesterase to membrane rafts: a function mediated by the proline-rich membrane anchor (PRiMA) in neurons.

Pub. Date : 2010 Apr 9

PMID : 20147288






2 Functional Relationships(s)
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1 In NG108-15 neuroblastoma cells transfected with cDNAs encoding AChE(T) and PRiMA, PRiMA-linked G(4) AChE was found in membrane rafts and showed the same sensitivity to cold Triton X-100 extraction as in the brain. Octoxynol acetylcholinesterase (Cartwright blood group) Homo sapiens
2 The cytoplasmic domain of PRiMA, which differs between PRiMA I and PRiMA II, appeared to play some role in stabilizing the raft localization of G(4) AChE, because the Triton X-100-resistant fraction was smaller with the shorter PRiMA II isoform than that with the longer PRiMA I isoform. Octoxynol acetylcholinesterase (Cartwright blood group) Homo sapiens