Title : Suppression of mutagenesis by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by human MTH1, MTH2, and NUDT5.

Pub. Date : 2010 May 1

PMID : 20144704






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 To assess the functions of the three human MutT-type enzymes, MTH1, MTH2, and NUDT5, mutation induction by an oxidized form of dGTP, 8-hydroxy-2"-deoxyguanosine 5"-triphosphate (8-OH-dGTP; 7,8-dihydro-8-oxo-2"-deoxyguanosine 5"-triphosphate), was examined using human 293T cells treated with their specific siRNAs. deoxyguanosine triphosphate nudix hydrolase 1 Homo sapiens
2 These results indicate that all three of the human MTH1, MTH2, and NUDT5 proteins act as a defense against the mutagenesis induced by oxidized dGTP. deoxyguanosine triphosphate nudix hydrolase 1 Homo sapiens