Title : Adenosine A(2)A receptor but not HIF-1 mediates Tyrosine hydroxylase induction in hypoxic PC12 cells.

Pub. Date : 2010 Jul

PMID : 20143408






3 Functional Relationships(s)
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1 Adenosine is released in response to hypoxia in the central nervous system and CGS21680, an adenosine A(2)A receptor agonist, induces TH transcription. Adenosine tyrosine hydroxylase Rattus norvegicus
2 As we have previously demonstrated the A(2)A receptor-mediated induction of HIF-1 in macrophages and hepatocytes, we investigated the involvement of HIF-1 in the adenosine-mediated activation of TH expression. Adenosine tyrosine hydroxylase Rattus norvegicus
3 Exposure to adenosine or CGS21680 increased TH mRNA and protein levels in PC12 cells. Adenosine tyrosine hydroxylase Rattus norvegicus