Title : Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations.

Pub. Date : 2010 Feb 15

PMID : 20142433






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Recombinant IDH1 R132C and IDH2 R172K proteins catalyze the novel nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of alpha-ketoglutarate (alpha-KG) to 2-HG. NADP isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens
2 Recombinant IDH1 R132C and IDH2 R172K proteins catalyze the novel nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of alpha-ketoglutarate (alpha-KG) to 2-HG. NADP isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens