Title : Molecular basis of S100 proteins interacting with the p53 homologs p63 and p73.

Pub. Date : 2010 Apr 8

PMID : 20140014






2 Functional Relationships(s)
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1 We found that S100A1, S100A2, S100A4, S100A6 and S100B proteins bound different p63 and p73 tetramerization domain variants and naturally occurring isoforms with varying affinities in a calcium-dependent manner. Calcium S100 calcium binding protein B Homo sapiens
2 The regulation of the p53 family by S100 is complicated and depends on the target preference of each individual S100 protein, the concentration of the proteins and calcium, as well as the splicing variation of p63 or p73. Calcium S100 calcium binding protein B Homo sapiens