Title : The epoxyeicosatrienoic acid-stimulated phosphorylation of EGF-R involves the activation of metalloproteinases and the release of HB-EGF in cancer cells.

Pub. Date : 2010 Feb

PMID : 20139904






1 Functional Relationships(s)
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1 In addition, AG1478, 1,10-phenanthroline, and CRM197 also inhibited the tyrosine phosphorylation of EGF-R and ERK1/2 that was induced by 14,15-EET in the A549, HepG2, and MDA-MB-231 cell lines. 14,15-epoxy-5,8,11-eicosatrienoic acid mitogen-activated protein kinase 3 Homo sapiens