Title : Inflammatory stimulation and hypoxia cooperatively activate HIF-1{alpha} in bronchial epithelial cells: involvement of PI3K and NF-{kappa}B.

Pub. Date : 2010 May

PMID : 20139176






1 Functional Relationships(s)
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1 The activation of HIF-1alpha by TNFalpha/IL-4 was countered by the phosphoinositol 3-kinase (PI3K) inhibitor LY-294002 and rapamycin, an antagonist of mammalian target of rapamycin (mTOR), but not by inhibition of the MAPK pathway. Sirolimus tumor necrosis factor Homo sapiens