Title : The inhibitory effect of hesperidin on tumor cell invasiveness occurs via suppression of activator protein 1 and nuclear factor-kappaB in human hepatocellular carcinoma cells.

Pub. Date : 2010 Apr 15

PMID : 20138977






2 Functional Relationships(s)
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1 First, we suggest that the expression of MMP-9 by TPA involves phosphorylation of IKK, p38, and PKC in hepG2. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 14 Homo sapiens
2 Hesperidin suppressed TPA-stimulated NF-kappaB translocation into the nucleus through IkappaB inhibitory signaling pathways and also inhibited TPA-induced AP-1 activity by the inhibitory phosphorylation of p38 kinase and c-Jun N-terminal kinase (JNK) signaling pathways. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 14 Homo sapiens